解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We investigate the optical wavelength dependence in quantitative photoacoustic (QPA) assessment of red blood cell (RBC) aggregation and oxygen saturation (sO2 ) during pulsatile blood flow. Experimentally, the pulsatile flow was imaged with a 700 to 900 nm laser using the VevoLAZR. Theoretically, the photoacoustic (PA...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700300
更新日期:2018-08-01 00:00:00
abstract::Basidiomycetes, that is, mushroom-type fungi, are known to produce pigments in response to environmental impacts. As antioxidants with a high level of unsaturation, these compounds can neutralize highly oxidative species. In the event of close contact with other microbes, the enzymatically controlled pigment productio...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700369
更新日期:2018-06-01 00:00:00
abstract::Malaria is a life-threatening infectious blood disease affecting humans and other animals caused by parasitic protozoans belonging to the Plasmodium type especially in developing countries. The gold standard method for the detection of malaria is through the microscopic method of chemically treated blood smears. We de...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700279
更新日期:2018-05-01 00:00:00
abstract::We develop a confocal system equipped with optimal elliptical apertures to improve axial point spread function and signal-to-background ratio (SBR) for different detector sizes. By adjusting the parameters of the elliptical apertures, the axial half width at half-maximum can be reduced to 4.986 (described in optical c...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700293
更新日期:2018-05-01 00:00:00
abstract::Laser treatment on a large size of prostate gland often encounters significant bleeding that can prolong the entire procedure and cause urinary complications. The current study investigates the feasibility of dual-wavelength (532 and 980 nm) application to achieve rapid hemostasis for 532-nm laser prostatectomy. Porci...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700192
更新日期:2018-04-01 00:00:00
abstract::Near-infrared light allows measuring tissue oxygenation. These measurements relay on oxygenation-dependent absorption spectral changes. However, the tissue scattering, which is also spectral dependent, introduces an intrinsic error. Most methods focus on the volume reflectance from a semi-infinite sample. We have prop...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700208
更新日期:2018-04-01 00:00:00
abstract::Photoacoustic microscopy (PAM) provides a fundamentally new tool for a broad range of studies of biological structures and functions. However, the use of PAM has been largely limited to small vertebrates due to the large size/weight and the inconvenience of the equipment. Here, we describe a portable optical-resolutio...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700250
更新日期:2018-04-01 00:00:00
abstract::The ability to provide quantitative, objective and automated pathological analysis would provide enormous benefits for national cancer screening programmes, in terms of both resource reduction and improved patient wellbeing. The move towards molecular pathology through spectroscopic methods shows great promise, but ha...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700244
更新日期:2018-04-01 00:00:00
abstract::223 Radium (223 Ra) is widely used in nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice 223 Ra cannot be imaged directly; however, gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work, we show that 223 Ra ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700209
更新日期:2018-04-01 00:00:00
abstract::Spahr et al. recently commented on our latest paper "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" with a conclusion that the measured retinal pulse wave velocity (rPWV) in our paper was contradictory to theoretical predictions and previously published results. However, th...
journal_title:Journal of biophotonics
pub_type: 评论,杂志文章
doi:10.1002/jbio.201700379
更新日期:2018-02-01 00:00:00
abstract::This paper comments on the article "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" by Qian Li et al. The authors propose a method to determine the pulse wave velocity in retinal arteries and veins. This method should enable a noninvasive determination of biomechanical prope...
journal_title:Journal of biophotonics
pub_type: 评论,杂志文章
doi:10.1002/jbio.201700347
更新日期:2018-02-01 00:00:00
abstract::Three-dimensional reconstruction of tissue structures is essential for biomedical research. The development of light microscopes and various fluorescent labeling techniques provides powerful tools for this motivation. However, optical imaging depth suffers from strong light scattering due to inherent heterogeneity of ...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201700187
更新日期:2018-02-01 00:00:00
abstract::Molecular bioswitches offer an invaluable asset in the shift from systemic to targeted treatments. Within the growing arsenal of switches are imaging probes that functionalize only in given locations or situations. Acetate esters are a common fluorescent example, known to activate upon interaction with esterases. Fluo...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700084
更新日期:2018-02-01 00:00:00
abstract::It is well known that, under exposure to bright light, eggs tend to hatch earlier than control, without any damage to the birds. This report aims to systematically show the effect and establishes a proposal for a possible application to accelerate chicken egg formation, which could be extrapolated or adapted as a grea...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700046
更新日期:2018-02-01 00:00:00
abstract::A multiple exposure laser speckle contrast imaging (MELSCI) setup for visualizing blood perfusion was developed using a field programmable gate array (FPGA), connected to a 1000 frames per second (fps) 1-megapixel camera sensor. Multiple exposure time images at 1, 2, 4, 8, 16, 32 and 64 milliseconds were calculated by...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700069
更新日期:2018-02-01 00:00:00
abstract::Zinc metallized Phthalocyanine (ZnPcSmix ), a potent photosensitizer, is conjugated to gold dendrimer encapsulated nanoparticles (AuDENPs) in order to improve the efficacy of photodynamic therapy (PDT) using MCF-7 breast cancer cells and WS1 fibroblast cells as a control. Both ZnPcSmix and AuDENPs are mixed in a nitro...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700077
更新日期:2018-02-01 00:00:00
abstract::We report the use of ultrasound modulated optical tomography (UOT) with heterodyne parallel detection to locally sense and image blood flow deep inside a highly scattering medium. We demonstrate that the UOT signal is sensitive to the speed of the blood flow in the ultrasound focus and present an analytical model that...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700013
更新日期:2018-01-01 00:00:00
abstract::Biophotonics is a highly interdisciplinary field where physicists, chemists, biologists, physicians and engineers work together to solve the problems appearing in biology and medicine. In China, the Biophotonics discipline is often referred to as Biomedical Photonics, under the first-level disciplines Biomedical Engin...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201790012
更新日期:2017-12-01 00:00:00
abstract::Micro-/nanosphere-mediated femtosecond laser cell perforation is one of the high throughput technologies used for macro-molecule-delivery into multiple cells. We have demonstrated the delivery of plasmid-DNA/liposome complexes into cells using biodegradable polymer microspheres and a femtosecond laser and investigated...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600323
更新日期:2017-12-01 00:00:00
abstract::Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600241
更新日期:2017-12-01 00:00:00
abstract::Lasers/LEDs demonstrate therapeutic effects for a range of biomedical applications. However, a consensus on effective light irradiation parameters and efficient and reliable measurement techniques remain limited. The objective here is to develop, characterise and demonstrate the application of LED arrays in order to p...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600273
更新日期:2017-11-01 00:00:00
abstract::Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and treatment that would completely eradicate the virus in infected individuals, th...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600217
更新日期:2017-10-01 00:00:00
abstract::Compared to conventional techniques, Laser surgery procedures provide a number of advantages, but may be associated with an increased risk of iatrogenic damage to important anatomical structures. The type of tissue ablated in the focus spot is unknown. Laser-Induced Breakdown-Spectroscopy (LIBS) has the potential to g...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600153
更新日期:2017-10-01 00:00:00
abstract::Intraoperative detection of residual malignant cells at tumor margins following excision of primary tumors could help improving surgery and thus patients' outcome. The feasibility of the tumor antigens epidermal growth factor receptor (EGF-R) and epithelial cell adhesion molecule (EpCAM) for antibody-dependent confoca...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600238
更新日期:2017-10-01 00:00:00
abstract::A conceptually new type of corneal inlays for a customized treatment of presbyopia is presented. The diffractive inlay consists on a small aperture disc having an array of micro-holes distributed inside the open zones of a Fresnel zone plate. In this way, the central hole of the disc lets pass the zero order diffracti...
journal_title:Journal of biophotonics
pub_type: 信件
doi:10.1002/jbio.201600320
更新日期:2017-09-01 00:00:00
abstract::Monitoring living cells in real-time is important in order to unravel complex dynamic processes in life sciences. In particular the dynamics of initiation and progression of degenerative diseases is intensely studied. In atherosclerosis the thickening of arterial walls is related to high lipid levels in the blood stre...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600279
更新日期:2017-09-01 00:00:00
abstract::A wide variety of subcutaneous soft-tissue masses may be seen in clinical practice. Clinical examination based on palpation alone is often insufficient to identify the nature and exact origin of the mass, in which case imaging is necessary. We used handheld multispectral optoacoustic imaging technology (MSOT) in a pro...
journal_title:Journal of biophotonics
pub_type: 信件
doi:10.1002/jbio.201600274
更新日期:2017-08-01 00:00:00
abstract::Photoacoustic imaging (PAI) is a hybrid imaging modality with high resolution and sensitivity that can be beneficial for cancer staging. Due to insufficient endogenous photoacoustic (PA) contrast, the development of exogenous agents is critical in targeting cancerous tumors. The current study demonstrates the feasibil...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600159
更新日期:2017-08-01 00:00:00
abstract::The ability to resolve multiple fluorescent emissions from different biological targets in video rate applications, such as endoscopy and intraoperative imaging, has traditionally been limited by the use of filter-based imaging systems. Hyperspectral imaging (HSI) facilitates the detection of both spatial and spectral...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600304
更新日期:2017-06-01 00:00:00
abstract::Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In thi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600047
更新日期:2017-06-01 00:00:00
abstract::Skin optical clearing has shown tremendous potential in improving various optical imaging performances, but there is some certain blindness in screening out high-efficiency in vivo optical clearing methods. In this work, three optical clearing agents: sucrose (Suc), fructose (Fruc) and PEG-400 (PEG), and two chemical ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600221
更新日期:2017-06-01 00:00:00
abstract::The purpose of this study was to evaluate thermal and near-infrared (NIR) reflectance imaging methods for the assessment of the activity of root caries lesions. In addition, changes in the lesion structure were monitored with polarization sensitive optical coherence tomography (PS-OCT). Artificial bovine and natural r...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500333
更新日期:2017-03-01 00:00:00
abstract::This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, t...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201600290
更新日期:2016-12-01 00:00:00
abstract::Ionizing radiation (IR) induces DNA damage and low-level laser therapy (LLLT) has been investigated to prevent or repair detrimental outcomes resulting from IR exposure. Few in vitro studies, however, explore the biological mechanisms underlying those LLLT benefits. Thus, in this work, fibroblasts and tumor cells are ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600107
更新日期:2016-12-01 00:00:00
abstract::Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of skin fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600059
更新日期:2016-12-01 00:00:00
abstract::Photobiomodulation (PBM) therapy has been noted to promote cell proliferation and growth in many different cell types shown both in vitro and in vivo. Currently, treatment regimens are used in the clinic for a variety of ailments, including wound healing. However, most protocols treat an anatomical site without consid...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600025
更新日期:2016-12-01 00:00:00
abstract::Low-power laser irradiation (LPLI) has been extensively employed to modulate inflammation in vitro and in vivo. Previous reports from our group indicated that LPLI might regulate glycemia in diabetic animals. Diabetes results in chronic hyperglycemia and therefore chronic inflammation by upregulation of inflammatory m...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600175
更新日期:2016-12-01 00:00:00
abstract::Photodynamic therapy (PDT) uses photosensitizers and visible light in combination with molecular oxygen to produce reactive oxygen species (ROS) that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature and stimulate the host immune system. The excited singlet state of oxygen (1 O2 )...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201600055
更新日期:2016-12-01 00:00:00
abstract::5-aminolevulinic acid (ALA) and its methylated ester (MAL) are the most common topical agents used in photodynamic therapy (PDT) as precursors of the photosensitizer protoporphyrin IX (PpIX). The induction of newly PpIX depends on incubation time of each photosensitizer in the tissue and the presence of high intralesi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600164
更新日期:2016-12-01 00:00:00
abstract::Low-level laser therapy (LLLT) is known to enhance mitochondrial electron transfer and ATP production; thus, this study asked whether LLLT could stimulate the oxidative burst in human neutrophils (PMN) and improve their ability to kill microorganisms. Blood from healthy human subjects was collected and PMN were isolat...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600035
更新日期:2016-12-01 00:00:00